Based on the results of these tests, some patients may have additional blood tests to check hormone response to special foods, an IV salt solution, or other hormones or drugs given either IV or by mouth (in pill form). After the stimulus, blood is drawn through the same IV every 30 minutes for up to 3 hours to measure hormone levels. The hormones are given through an intravenous catheter, or IV a thin plastic tube inserted into an arm vein. Blood tests to see if the tumor secretes hormones in response to specific stimuli, including exercise, food, and various hormones.Imaging studies, including magnetic resonance imaging (MRI) of the brain, computed tomography (CT) and other X-ray studies.24-hour urine collection to measure hormones in the urine.Children and adolescents will have Tanner staging, including examination of the genitals, to determine the extent of sexual maturity. Medical history and physical examination, including body measurements, as appropriate.Participants will be hospitalized for 7 to 10 days for various tests and procedures that may include the following: Patients between 3 and 70 years old with a known or suspected adrenal gland tumor may be eligible for this study. This study will investigate how adrenal gland tumors develop, why some secrete steroid hormones and others do not, and why some are benign and others malignant.
Some of the tumors are benign and confined to the adrenal gland, and others are malignant (cancerous), and can spread to other parts of the body. It is not known what causes these tumors or why some secrete hormones and others do not. Tumors of these glands may or may not secrete hormones. The adrenal glands, located atop the kidneys, normally produce several types of hormones. Why Should I Register and Submit Results?.
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